喹啉铜在枇杷上的消解、储藏稳定性及风险评估
目的 评估喹啉铜在枇杷中的残留消解、储藏稳定性和慢性膳食风险。方法 实验样品用草酸溶液提取, 亲水亲脂平衡(hydrophilic-lipophilic balance, HLB)固相萃取柱净化, 超高效液相色谱检测, 外标法定量, 评估储藏稳定性和慢性膳食风险。结果 喹啉铜在枇杷上的消解速率符合一级动力学方程, 半衰期为3.4~ 4.6 d。枇杷样品在–18 ℃储藏150 d, 喹啉酮的降解率小于30%。膳食风险评估结果表明, 各年龄段人群喹啉铜的估算每日摄入量为0.0891~0.6945 μg/kg bw/d, 膳食摄入风险为0.45%~3.47%。结论 喹啉铜在枇杷中消解较迅速; 喹啉铜在枇杷样品中储藏稳定期至少为150 d; 对不同年龄阶段人群的长期慢性膳食暴露风险极低, 均在可接受范围之内。
Objective To evaluate the residual digestion, storage stability and chronic dietary risks of oxine-copper in toloquat. Methods Loquat samples were extracted with oxalic acid, purified with hydrophilic-lipophilic balance (HLB) solid phase extraction column, finally detected by ultra performance liquid chromatography. The samples were quantified by external standard method. The storage stability and chronic dietary risk were assessed. Results The digestion rate of oxine-copper in loquat followed the first-order kinetics. The half-lives of oxine-copper in loquat were 3.4~4.6 d. Loquat samples were stored at –18 ℃ for 150 d, and the degradation rate of oxine-copper was less than 30%. The results of dietary risk assessment indicated that the estimated daily intake of oxine-copper for all age groups was 0.0891-0.6945 μg/kg bw/d, and the dietary intake risk was 0.45%-3.47%. Conclusion The digestion of oxine-copper in loquat was rapid. The stable storage period of oxine-copper in loquat samples is at least 150 d. The risk of long-term chronic dietary exposure for people of different ages is extremely low and within the acceptable range.
标题：喹啉铜在枇杷上的消解、储藏稳定性及风险评估
英文标题：Evaluation of residual digestion, storage stability and chronic dietary risk of oxine-copper in loquat
作者：
徐小军 浙江医药高等专科学校
付岩 宁波市农业科学研究院
王全胜 宁波市农业科学研究院
张亮 宁波市农业科学研究院
吴银良 宁波市农业科学研究院
中文关键词:喹啉铜,枇杷,消解,储藏稳定性,风险评估,
英文关键词:oxine-copper,loquat,dissipation,storage stability,risk assessment,
发表日期：2020-04-09
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