透明质酸胶原蛋白冰糖燕窝饮品安全性及有效性评价
目的 评价透明质酸胶原蛋白冰糖燕窝饮品的安全性及改善皮肤水分的功能。方法 采用小鼠急性经口毒性试验、小鼠精子畸形试验、小鼠骨髓细胞微核试验、Ames试验、30 d喂养试验对其进行安全性评价; 通过人体受试试验, 评价其对人体皮肤水分改善情况。结果 透明质酸胶原蛋白冰糖燕窝饮品经口最大耐受剂量(maximum tolerated dose, MTD)大于20.00 g/kg?BW, 相当于人体推荐剂量的200倍, 属无毒级, 小鼠精子畸形试验、小鼠骨髓嗜多染红细胞微核试验、Ames试验结果均为阴性, 30 d喂养试验各剂量组血常规指标、血生化指标于空白和酪蛋白对照组比较, 无显著差异(P＞0.05); 人体试验中试验组皮肤水分提高约10.54%。结论 透明质酸胶原蛋白冰糖燕窝饮品具有改善皮肤水分的功能, 且安全无毒。
Objective To evaluate the safety of hyaluronic acid collagen rock candy bird's nest drink and its effectiveness on improvement of human skin moisture. Methods The safety of hyaluronic acid collagen rock candy bird's nest drink was evaluated by the acute toxicity in mice, the experiment of mouse sperm deformity, the mutation of salmonella test (Ames test) and the 30 d feeing test. Its effect on human skin moisture was evaluated by human test. Results The maximum tolerated dose (MTD) of hyaluronic acid collagen rock candy bird's nest drink was more than 20.00 g/ kg?BW, equaled to 30 times of human recommendatory dosage, which indicated that it was nontoxic. The results of mice sperm abnormality test, mice bone marrow polychromatic erythrocyte micronucleus test, and Ames test results were negative and there was no significant difference in blood routine index and blood biochemical index between blank group and casein control group in 30 d feeding test (P>0.05). The skin moisture of the text group increased by about 10.54%. Conclusion Hyaluronic acid collagen rock candy bird's nest drink is safe and can improve skin moisture, and is safe and non-toxic.
标题：透明质酸胶原蛋白冰糖燕窝饮品安全性及有效性评价
英文标题：Safety and effectiveness evaluation of hyaluronic acid collagen rock candy bird’s nest drink
作者：
查圣华 北京同仁堂健康药业股份有限公司
张兴龙 北京同仁堂健康药业股份有限公司
王俊亮 北京同仁堂健康药业股份有限公司
张宏 北京同仁堂健康药业股份有限公司
中文关键词:透明质酸,胶原蛋白,燕窝,人体试验,皮肤水分,
英文关键词:hyaluronic acid,collagen,bird's nest,human experiment,skin moisture,
发表日期：2019-06-13
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