两种猴头菇复合物对胃粘膜损伤的辅助保护研究
目的 研究2种猴头菇复合物对无水乙醇诱导的急性胃粘膜损伤模型辅助保护作用。方法 将70只SD大鼠按体重随机分为空白对照组、模型对照组、阳性对照组、配方1(猴头菇提取物+壳聚糖+沙棘籽油)低、高剂量组, 配方2(猴头菇提取物+壳聚糖)低、高剂量组, 10只/组, 连续灌胃30 d。末次给药后, 无水乙醇造模, 游标卡尺测量出血点或出血带的长度和宽度, 计算积分, 并进行病理组织学观察评分。结果 与空白对照组相比, 模型对照组肉眼观察评分及组织病理学评分显著升高, 有统计学差异(P<0.01); 与模型对照组相比, 阳性对照组和配方1和配方2高剂量组组织病理学评分及肉眼观察评分降低(P<0.05)。结论 2种猴头菇复合物对无水乙醇诱导的急性胃粘膜损伤模型具有辅助保护作用。
Objective To study the auxiliary protective effect of two kinds of Hericium erinaceus complexes on absolute ethanol-induced acute gastric mucosal injury model. Methods 70 SD rats were randomly divided into blank control group, model control group, positive control group, formula 1 (Hericium erinaceus extract + chitosan + sea buckthorn seed oil) low and high dose group, formula 2 (Hericium erinaceus extract + chitosan) low and high dose groups according to body weight, 10 rats per group, for 30 days of continuous gastric administration. After the last administration, the model was made with absolute ethanol gastric administration. The length and width of the bleeding point or bleeding band were measured with a Vernier caliper; the integral was calculated. The histopathological observation score was performed. Results Compared with the blank control group, the visual control score and histopathological score of the model control group were significantly increased, and there was a statistical difference (P<0.01). Compared with the model control group, the histopathological score and macroscopic score of the positive control group, the formula 1 and formula 2 high-dose group decreased (P<0.05). Conclusion Two kinds of Hericium erinaceus complexes have a auxiliary protective effect on absolute ethanol-induced acute gastric mucosal injury model.
标题：两种猴头菇复合物对胃粘膜损伤的辅助保护研究
英文标题：Study on the auxiliary protective effect of two kinds of Hericium erinaceus complex on gastric mucosa injury
作者：
欧慧瑜 广州医药研究总院有限公司药物非临床评价研究中心
吕道俊 广州医药研究总院有限公司药物非临床评价研究中心
郭秋平 广州医药研究总院有限公司药物非临床评价研究中心
李瑞鹏 广州医药研究总院有限公司药物非临床评价研究中心
中文关键词:猴头菇复合物,无水乙醇,急性胃粘膜损伤模型,
英文关键词:Hericium erinaceus complex,absolute ethanol,acute gastric mucosal injury model,
发表日期：2020-03-12
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