气相色谱-质谱联用法快速检测乳类化妆品中6种合成麝香
目的 建立同时、快速测定化妆品中葵子麝香、佳乐麝香、二甲苯麝香、麝香酮、吐纳麝香和酮麝香6种人造麝香的气相色谱-质谱联用分析方法。方法 以面霜、沐浴露、面膜等不同基质的化妆品为试样, 选用乙酸乙酯进行提取, 固相萃取(solid phase extraction, SPE)小柱净化, 采用气相色谱-质谱联用外标法进行分析。结果 葵子麝香、佳乐麝香、二甲苯麝香、麝香酮、吐纳麝香和酮麝香6种人造麝香在0.02~0.50 μg/mL浓度范围内线性良好, 相关系数为0.9968~0.9992。空白样品添加水平分别为0.20、0.40、2.00 mg/kg 时, 回收率在83.0%~110.38 %之间, 相对标准偏差在2.8%～7.5%之间, 以上6种人造麝香的方法检出下限在20.0～40.0 μg/kg之间。结论 本方法简单、快速、准确, 可满足化妆品中6种人造麝香的同时检测及确证需求。
Objective To establish a method of determination of 6 kinds of artificial musk (musk ambrette, galaxolide, musk xylene, ketone musk, tonalid and musk ketone) in cosmetics by gas chromatography-mass spectrometry (GC-MS). Methods Totally 6 kinds of artificial musk residues were extracted from the samples (cream, body wash, facial mask, etc) with ethyl acetate, cleaned up by solid phase extraction (SPE), then detected by GC-MS with external standard method. Results The 6 kinds of artificial musk had good linear relationship in the range of 0.02~0.50 μg/mL with correlation coefficients of 0.9968~0.9992. The recoveries of all artificial musk were 83.0%~110.38% at the spiked levels of 0.20, 0.40 and 2.00 mg/kg in cosmetics, and the relative standard deviations (RSD) were 2.8%~7.5%. The limits of detection (LODs) of 6 kinds of artificial musk were 20.0～40.0 μg/kg. Conclusion This method is simple, rapid and accurate, which is suitable for the simultaneous determination of 6 kinds of artificial musk in cosmetics.
标题：气相色谱-质谱联用法快速检测乳类化妆品中6种合成麝香
英文标题：Rapid determination of 6 kinds of artificial musk in cosmetics by gas chromatography-mass spectrometry
作者：
李菊 华南农业大学,广东出入境检验检疫局
方祥 华南农业大学
谢建军 广东出入境检验检疫局
黄雪琳 东莞出入境检验检疫局
黄伟 东莞出入境检验检疫局
陈文锐 广东出入境检验检疫局
王志元 广东出入境检验检疫局
中文关键词:人工合成麝香,气相色谱-质谱法,化妆品,
英文关键词:artificial musk,gas chromatography-mass spectrometry,cosmetics,
发表日期：2017-05-05
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