葛根发酵液对原发性高血压大鼠的降血压作用
目的 分析葛根发酵液对原发性高血压大鼠(spontaneously hypertensive rat, SHR)的降血压作用。方法 利用植物乳杆菌发酵葛根汁得到葛根发酵液, 将SHR大鼠随机分为6组, 空白对照组、依那普利组、葛根汁组、葛根发酵液低、中、高剂量组。通过不同剂量的单次灌胃和5周连续灌胃给药实验, 测定受试动物的血压情况及血液中一氧化氮(NO)和超氧化物歧化酶(SOD)的含量, 分析葛根发酵液的降血压能力。结果 与空白对照组和葛根汁组相比, 葛根发酵液低、中、高剂量组的SHR大鼠的血压显著降低(P0.05)。结论 葛根发酵液对SHR大鼠具有良好的降血压作用。
Objective To analyze the effects of puerarin fermented liquid (PFL) on reducing blood pressure of spontaneously hypertensive rats (SHR). Methods The puerarin juice was fermented with Lactobacillus plantarum to obtain the PFL. The SHR were randomly divided into 6 groups, which included control group, enalaprilat group, puerarin juice group, low, middle and high dose group of PFL. Through the single and long-term (5 weeks) lavage experiments, the antihypertensive effects of PFL were analyzed by determining the changes of blood pressure and content of nitric oxide (NO) and superoxide dismutase (SOD) in blood of SHR. Results Compared with control group and puerarin juice group, the blood pressures of SHR treated with low, middle and high dose of PFL were significantly reduced (P0.05). Conclusion The PFL has a good antihypertensive effect to SHR.
标题：葛根发酵液对原发性高血压大鼠的降血压作用
英文标题：Effects of puerarin fermented liquid on reducing blood pressure of spontaneously hypertensive rats
作者：
苏蕾 内蒙古医科大学附属医院
苏改生 内蒙古医科大学附属医院
中文关键词:葛根发酵液,原发性高血压大鼠,降血压,一氧化氮,超氧化物歧化酶,
英文关键词:puerarin fermented liquid,spontaneously hypertensive rat,antihypertensive effect,nitric oxide,superoxide dismutase,
发表日期：2016-08-01
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