肉苁蓉膳食纤维润肠通便功能研究
目的 研究肉苁蓉膳食纤维的润肠通便功能, 为开发利用肉苁蓉膳食纤维提供科学依据。方法 依据国标方法对制得的肉苁蓉膳食纤维进行主要成分分析, 将实验小鼠随机分为5组, 包括正常对照组、便秘模型组和肉苁蓉膳食纤维低、中、高剂量组。以复方地芬诺酯建立便秘模型, 通过测定小鼠的小肠活性炭推进率、首粒黑便的排出时间及其之后6 h内的排便粒数, 评价肉苁蓉膳食纤维对小鼠润肠通便功能的影响。结果 本研究制得的肉苁蓉膳食纤维中含有88.12%的可溶性膳食纤维。在连续灌胃14天后, 肉苁蓉膳食纤维各剂量组小鼠的小肠活性炭推进率均高于便秘模型组, 其中, 中、高剂量组与便秘模型组间有显著性差异(P＜0.05); 与模型组相比, 肉苁蓉膳食纤维各剂量组小鼠的首粒黑便排出时间均有所缩短, 6 h排便粒数均有所增加,其中, 高剂量组小鼠的首粒黑便排出时间和6 h排便粒数与模型组相比具有显著性差异(P<0.05)。结论 肉苁蓉膳食纤维具有良好的润肠通便功能。
Objective To study the laxative function of dietary fiber from Cistanche deserticola (CDDF) and provide scientific basis for its exploration and utilization. Methods The main compositions of CDDF were analyzed according to the national standards. The experimental mice were randomly divided into 5 groups including normal control, constipation model group and CDDF groups with low, middle and high doses. The constipation model was established by compound diphenoxylate tablets. The effects of CDDF on the laxative function of mice were evaluated by the active carbon propelling rate in small intestinal, defecation time of the first black feces and granule number of feces within 6 h. Results The content of soluble dietary fiber in CDDF prepared in this study was 88.12%. The active carbon propelling rates of small intestinal in mice of CDDF groups were all higher than those of constipation model group, and significant differences were found between the model group and the middle dose group or high dose group (P<0.05). Compared with the model group, the defecation time of the first black feces in CDDF groups was shortened, and the granule number of feces within 6 h was increased, especially for the high dose group (P<0.05). Conclusion The CDDF plays an important role in the laxative function.
标题：肉苁蓉膳食纤维润肠通便功能研究
英文标题：Laxative function of dietary fiber from Cistanche deserticola
作者：
王丽卫 中国科学院过程工程研究所生化工程国家重点实验室
孙健 广西医科大学基础医学院
赵兵 中国科学院过程工程研究所生化工程国家重点实验室
赵明霞 中国科学院过程工程研究所生化工程国家重点实验室
中文关键词:肉苁蓉,膳食纤维,便秘模型,润肠通便,
英文关键词:Cistanche deserticola,dietary fiber,constipation model,laxative function,
发表日期：2016-08-15
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