一种新型他达拉非衍生物的分离和鉴定
目的 分离、鉴定一种新型他达拉非衍生物的结构。方法 在液相色谱-串联质谱法对保健食品“金博大”的日常检测中, 发现了一种可能的他达拉非衍生物, 通过高效液相制备该化合物, 并通过紫外光谱、精确分子量及串联质谱的信息推测该化合物的结构, 经核磁共振及文献比对确证其结构。结果 确证该化合物为2-羟乙基去甲基他达拉非(2-hydroxyethylnortadalafil), 是一种新型的他达拉非衍生物。结论 该化合物对人体可能产生的潜在危害认知较为有限, 需引起关注。该类化合物的紫外及质谱行为规律可提供丰富的化合物信息, 有助于新型衍生物结构的推测。
Objective To isolate and identify the structure of a new type of tadalafil analogue. Methods The compound was detected during routine screenings of dietary supplements-“JINBODA” by liquid chromatography- mass spectrometry (LC-MS), which displayed structural similarities with tadalafil. It was isolated from the supplements using preparative high performance liquid chromatography. The structure of the compound was estimated by ultra violet, accurate mass and LC-MS analyses, and its structure was further characterized using NMR and textual comparison. Results The compound was identified and confirmed as 2-hydroxyethylnortadalafil, which was a new analogue of tadalafil. Conclusion The compound may cause toxicological or pharmacological effects to public health and should be concerned, but there is little information on the potential risk. UV and mass spectrometric behaviors of this kind of compounds can provide abundant compounds information, which is beneficial to speculate the new derivative structure.
标题：一种新型他达拉非衍生物的分离和鉴定
英文标题：Isolation and identification of a new type of tadalafil analogue
作者：
冯睿 上海市食品药品检验所
于泓 上海市食品药品检验所
孙健 上海市食品药品检验所
胡青 上海市食品药品检验所
张甦 上海市食品药品检验所
毛秀红 上海市食品药品检验所
季申 上海市食品药品检验所
中文关键词:他达拉非衍生物,PDE-5抑制剂,非法添加,
英文关键词:tadalafil analogue,phosphodiesterase 5 inhibitor,adulteration,
发表日期：2016-06-03
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