牛乳β-乳球蛋白过敏原表位及其潜在应用
过敏原表位是过敏原直接参与免疫反应的物质基础, 也是导致过敏反应的“元凶”。牛乳β-乳球蛋白是lipocalin家族的代表和常用模式蛋白, 它的表位信息比较完整, 拥有7个人血清IgE和6个IgG的线性表位、3个IgE结合的构象性表位以及7个T细胞表位。另外, 它的动物源血清IgE、IgG和T细胞表位也在不断被发现。牛乳β-乳球蛋白的表位信息为基于表位的应用提供了重要的支撑, 它们的应用主要涉及到预测食物过敏原的致敏性, 食物过敏的交叉反应, 食物过敏的诊断, 食物过敏的免疫治疗以及食物过敏原的检测等5个方面。
Epitopes is the binding sits between allergen and the relevant antibody, and it is the triggering element of immune reaction. Bovine β-lactoglobulin belongs to lipocalin family and is one of the model proteins. It was found that 7 IgE binding and 6 IgE binding linear epitopes, 3 IgE binding conformational epitopes and 7 T cells binding epitopes existed in milk allergy patients, and the binding epitopes of other animal resource were also reported. The epitopes information plays a very important role in the application based on epitopes, and the application includes the prediction of food allergen allergenicity, cross-reactivity of food allergen, diagnosis of food allergy, immunotherapy of food allergy and analysis of food allergen.
标题：牛乳β-乳球蛋白过敏原表位及其潜在应用
英文标题：Epitopes on bovine β-lactoglobulin and its potential application
作者：
陈红兵 1.南昌大学食品科学与技术国家重点实验室；2.南昌大学中德联合研究院
中文关键词:牛乳过敏,表位,β-乳球蛋白,
英文关键词:milk allergy,epitope,β-lactoglobulin,
发表日期：2012-08-11
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