高效液相色谱-串联质谱法测定饮料、牛奶和奶粉中双酚A和15种邻苯二甲酸酯

高效液相色谱-串联质谱法测定饮料、牛奶和奶粉中双酚A和15种邻苯二甲酸酯
目的  建立了饮料、牛奶和奶粉中双酚A及15种邻苯二甲酸酯的高效液相色谱?串联质谱分析方法。方法  样品经甲醇提取, C18色谱柱分离后, 采用串联四极杆质谱电喷雾电离源正负离子切换多反应离子监测模式检测。结果  双酚A及15种邻苯二甲酸酯在各自的线性范围内线性关系良好, 相关系数均不低于0.9900, 定量下限为10 μg/kg, 低、中、高3个加标水平下平均回收率为61.1%~129.5%, 相对标准偏差为1.13%~22.12%。结论  该方法具有前处理简单、灵敏度高的优点, 适用于饮料、牛奶及奶粉中双酚A及15种邻苯二甲酸酯残留的确证和定量检测。

Objective  A method for the simultaneous determination of bisphenol A (BPA) and fifteen phthalate esters (PAEs) by high performance liquid chromatography-tandem mass spectrometry was established. Methods  The samples were extracted by methanol. The target compounds were separated by C18 column and detected by MS/MS system with eletrospray ionization (ESI) positive and negative ion mode under multiple reaction monitoring (MRM) mode. Results  High correlation coefficients (r≥0.9900) of sixteen compounds were obtained within their respective linear ranges. The LOQ of BPA and 15 PAEs was 10 μg/kg. The recov-eries ranged from 61.1%~129.5%, with the relative standard deviations of 1.13%~22.12%. Conclusion  This method is suitable for the identification and quantification of PAEs and BPA in beverage, milk and milk powder with advantages of simple pretreatment, good purification and high sensitivity.

标题：高效液相色谱-串联质谱法测定饮料、牛奶和奶粉中双酚A和15种邻苯二甲酸酯
英文标题：Determination of bisphenol A (BPA) and 15 phthalate esters (PAEs) by high performance liquid chromatography-tandem mass spectrometry in beverage, milk and milk powder

作者：
静平 山东出入境检验检疫局食品农产品中心
张金斗 青岛大学化学化工与环境学院
朱文彬 德州市疾病预防控制中心
鲍蕾 山东出入境检验检疫局食品农产品中心
于冰 青岛大学化学化工与环境学院
吴振兴 山东出入境检验检疫局食品农产品中心
梁成珠 山东出入境检验检疫局食品农产品中心

中文关键词:邻苯二甲酸酯,双酚A,高效液相色谱串联质谱,
英文关键词:phthalate esters,bisphenol A,high performance liquid chromatography-tandem mass spectrometry,

发表日期：2014-07-07

2025-1-28 18:48 上传 高效液相色谱-串联质谱法测定饮料、牛奶和奶粉中双酚A和15种邻苯二甲酸酯.pdf

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